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KMID : 0191119990140050497
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Journal of Korean Medical Science
1999 Volume.14 No. 5 p.497 ~ p.501
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Augmented expression of cardiac atrial natriuretic peptide system in hypertensive rats
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An MR
Chung YJ/Kang DG/Nam SC/Lee J
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Abstract
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The present study was aimed at investigating the regulation of atrial natriuretic peptide (ANP) system in
association with either enhanced or attenuated activity of the renin-angiotensin system (RAS). The cardiac
tissue mRNA and peptide levels of ANP were measured in rats with two-kidney, one clip (2K1C) or deoxycorticosterone
acetate (DOCA)-salt hypertension. Plasma renin concentration was increased in 2K1C hypertension along with
increases of renin mRNA and protein contents in the clipped kidney. On the contrary, it was suppressed in
DOCA-salt hypertension along with decreases of renin mRNA and protein contents in the remaining kidney.
The plasma ANP concentration was similarly increased in both models of hypertension. The cardiac tissue
ANP contents were not significantly changed, but the tissue ANP mRNA levels were upregulated in the
hypertrophied heart in these two models of hypertension. It is suggested that the cardiac ANP system
is transcriptionally enhanced by cardiac hypertrophy associated with hypertension, independent of the
systemic RAS.
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KEYWORD
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